Snapshot ECG recording in rodents

ECG average module

ecgAVG is a software module available within IOX2 software, or as a standalone module, to acquire and analyze average ECG beats.

This module is particularly recommended and well suited to analyze rodents ECG recordings acquired with the ecgTUNNEL device.

Indeed, as subject is conscious in the ecgTUNNEL, recorded data are typically variable in quality, and real time beat to beat analysis is generally not optimized.

Averaging ECG beats is a method that can drastically improve signal quality and facilitate further intervals analysis. Indeed, the ecgAVG module provides the ability to manually select time zones where signal quality is good enough for beats detection, averaging and analysis.

ecgAVG module allows:

• . Automatic detection of RR intervals from selected zone of ECG, amplitudes, QT correction etc.
• . Automatic computation of average ECG shape, from defined time period or beat numbers.
• . Manual placement of marks on average beat if required
• . Comprehensive report combining parameters and shapes evolution at different time points

Interdissciplinary studies

ecgAVG module is available from IOX2 software, which contains a library of application-specific analysis modules. Additional analyzers are available for cardiovascular, respiratory, neurological, electrophysiology and in-vitro data acquisition.

 Though ecgAVG module has been designed for rodent ECGs and the ecgTUNNEL device, it might be used to analyze the ECG of any specy.

ecgTUNNEL for non-invasive ECG recording 

ecgTUNNEL is a plug-and-play system for snapshot Electrocardiogram recordings and respiration data in rodents, that eliminates the need for surgery and anesthesia.

It combines up to 6-lead ECG with an optional plethysmograph dome for respiratory endpoints with optional exposure and infusion options. 

This set up is particularly useful for snapshot recordings during sessions lasting a few minutes. 

ecgTUNNEL is often used for longitudinal studies where the subjects are studied on successive experiment days, or when subjects are particularly fragile and cannot tolerate surgery or anesthesia.

Kimberly Londer BS, from the University of Maryland is using ecgTUNNEL to capture ECG on young mice, without anesthesia.

In an interview, she said, “there are few systems, publications, or data that exists on small animal ECG without the use of anesthesia or telemetry.”