---
title: Opioid Research with Plethysmography
description: SCIREQ  introduces the new vivoFlow-Whole Body Plethysmography Chamber at Experimental Biology 2019 in Orlando, Florida. Plethysmography captures breathing patterns in conscious, spontaneously breathing subjects.
image: https://emka.scireq.com/hubfs/vivoFlow.png
---

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# Opioid Research with Plethysmography

Get to know the new vivoFlow - Whole Body Plethysmograph Chamber at

**Experimental Biology 2019 in Orlando**.

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  Plethysmography captures breathing patterns in conscious, spontaneously breathing subjects.

**Opioid Research with Plethysmography**

![Asset 4@2x-100](https://emka.scireq.com/hs-fs/hubfs/Asset%204@2x-100.jpg?width=120&name=Asset%204@2x-100.jpg)

Central nervous system respiratory depression is a well-known side-effect of the opioid drug family and respiratory depression is the primary cause of fatal opioid overdose. 

Whole Body Plethysmography permits a continuous and noninvasive approach to assess changes in conscious respiratory behaviour which result from drug administration. It is the ideal approach to monitor the effects on respiratory functions of fentanyl, oxycodone, morphine and many others. 

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**Reference**

[Hill *et al.*](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003631/) examined both the signalling profile of the novel µ-opioid receptor ligand PZM21, and its capacity to induce respiratory depression. Respiratory rate and tidal volume were assessed using plethysmography, comparing saline control and morphine-treated subjects to those administered PZM21.

**Benefits of Plethysmography**

- Easy-to-use
- No surgery required![vivoFlow](https://emka.scireq.com/hs-fs/hubfs/vivoFlow.png?width=190&name=vivoFlow.png)
- Tracks conscious subjects' ability to respond to real-time changes
- Swivel/tether system for measurement of physiological parameters (EEG), drug infusion or blood sampling
- Integrates easily with gas challenges, through the use of automated mass flow controllers
- Measures respiratory rate (RR), estimated tidal volume (VT), minute ventilation (MV) and flow rates

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## PLETHYSMOGRAPHS: 

## FREELY MOVING vs. RESTRAINED

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![VF HEAD OUT AND DCP-1](https://emka.scireq.com/hs-fs/hubfs/VF%20HEAD%20OUT%20AND%20DCP-1.png?width=600&name=VF%20HEAD%20OUT%20AND%20DCP-1.png)

**Whole Body for Freely Moving Conscious Subjects**

In unrestrained whole body plethysmography (vivoFlow - WBP), the spontaneously breathing subject moves freely within a small, closed plethysmograph chamber. 

 

**Head Out for Restrained Subjects**

In head-out plethysmography (HOP), the subject is conscious, spontaneously breathing, and situated in a conical restraint. The conical restrainers follow the animal’s head shape.

 

**Double Chamber for Restrained Subjects**

In double chamber plethysmography (DCP), the head-out set-up is complemented with a head chamber, permitting delivery and containment of aerosolized compounds along with measurements of the specific airway resistance (sRaw) and conductance (sGaw) in a conscious subject.

 

 

**Other Applications for Plethysmography:**

- [Asthma and Airway Hyperresponsiveness](https://www.scireq.com/applications/asthma/)
- [Chronic Obstructive Pulmonary Disease (COPD)](https://www.scireq.com/applications/copd/)
- [Tobacco Studies, E-Cigarettes & Vaping](https://www.scireq.com/applications/tobacco-studies-e-cigarettes-vaping/)
- [Control of Breathing](https://www.scireq.com/control-breathing/)
- [Drug Development](https://www.scireq.com/applications/drug-development/)
- [Pediatrics & Neonatology](https://www.scireq.com/applications/pediatrics-neonatology/)
- [Pulmonary Fibrosis](https://www.scireq.com/applications/pulmonary-fibrosis/)

Visit  **booth 914**

 

See our range of sophisticated scientific tools for reproducible respiratory research.

 

 

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 **Booth  Dates & Hours:**

 

Sunday, April 7:           9 AM - 4 PM

Monday, April 8:          9 AM - 4 PM

Tuesday, April 9:          9 AM - 4 PM

 

**Floorplan**

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SCIREQ Scientific Respiratory Equipment Inc.  
 Head Office : 6600 St-Urbain Suite 300 Montreal, QC H2S 3G8 Canada  
 Telephone: Toll free [1 (877) 572-4737](tel:18775724737) or [1 (514) 286-1429](tel:1%205142861429)  
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